Using viral vectors to deliver local immunotherapy to glioblastoma
نویسندگان
چکیده
منابع مشابه
Short-term neuropathological aspects of in vivo suicide gene transfer to the F98 rat glioblastoma using liposomal and viral vectors.
To date, only few preclinical protocols on liposomal suicide gene transfer in tumors have been published, none of which directly compared viral to liposomal vectors in terms of immunoreactivity and efficacy. We thus studied the neuropathological alterations in 80 rats being treated for glioblastoma using liposomal and, for comparison, adenoviral and retroviral suicide gene transfer approaches t...
متن کاملApproaches to sensitizing glioblastoma to radiotherapy: use of lentiviral vectors.
Glioblastoma multiforme (GBM) is the most common primary brain tumour and extirpation followed by radio- and chemotherapy has had minimal impact on the median survival of patients which is still less than one year. Hence, a novel therapeutic modality is required if the survival of patients with this disease is to be improved. ATM, mutated in the h...
متن کاملTumour modelling using viral vectors
Human tumours typically harbour multiple mutations in tumour suppressor genes and oncogenes. Histologically identical tumours in different patients often exhibit different combinations of genetic alterations and it is now also evident that considerable genetic heterogeneity can exist between cells within individual tumours. A major ongoing research challenge remains to determine the functional ...
متن کاملHow to design and deliver a local teaching program
Teaching is an invaluable aspect of any medical or surgical career. Many trainees will find themselves delivering teaching at several stages in their career and in this "How to" article we explain how to design, set up, and deliver a successful teaching program, as well as how to evidence this in your portfolio.
متن کاملImmunotherapy of glioblastoma multiforme.
Glioblastoma multiforme is immunogenic and several glioblastoma multiforme-related antigens have now been identified. In addition, the immunologic characteristics of the tumor microenvironment that may affect tumor growth are becoming increasingly understood. The type of immune-based approach selected to treat glioblastoma multiforme will depend on the tumor burden. For minimal disease states, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurosurgical Focus
سال: 2021
ISSN: 1092-0684
DOI: 10.3171/2020.11.focus20859